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  • 2023〜

MedCheck No29 (May 2024)

MedCheck No 29 (May 2024) Download Corrected PDF Free

Contents
Editorial

Healthy vaccinee effect: a key bias in observational studies


Review

HPV vaccine increase total and cancer mortality without evidence of HPV-related cancer decrease

1.RCTs show increased cancer and total mortality
2. All observational studies failed to provide evidence for invasive cancer prevention
3.  Column: Healthy vaccinee effect in observational studies
Supplementary Appendix Free

Erratum
References 23 and 24 for the main text are corrected to as ffollows:
23) Wheeler CM, Skinner SR, Del Rosario-Raymundo MR, Garland SM, Chatterjee A, Lazcano-Ponce E, et al. Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double blind, randomised controlled VIVIANE study. Lancet Infectious Diseases 2016;16(10):1154-68.
24) Skinner SR, Szarewski A, Romanowski B, Garland SM, Lazcano-Ponce E, Salmeron J. Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised controlled VIVIANE study. Lancet 2014;384(9961): 2213–27.